The Extroducer Delivery Device

The Extroducer, first-in-class endovascular delivery device, is designed to deliver advanced therapies directly into hard to reach areas of the body. Due to the unique mechanical properties and design, in animal studies, multiple infusions could be performed in extravascular tissue after exit of the vascular system, opening the door for future research into precise cell and biologic therapy delivery and repurpose small molecules for greater and safe local effects.

Extroducer – unique advantages

  • Access tissue and organs difficult or risky to reach with conventional methods
  • Passes through the vascular wall directly into the tissue/organ
  • Precise, highly navigable with high injection accuracy in combination with guide/microcatheter
  • Rapid multiple injections to cover large part of any organ possible
  • Safe – no clinically significant bleeding or trauma to blood vessels and/or organs
  • Repeated access easy to achieve 
  • Easy to use – minimal training needed
  • Minimal dead space
Extroducer - unique advantages

Technology and innovation

Smartwise was founded in 2015 to develop the Extroducer technology invented in the laboratory of Staffan Holmin, MD, PhD, at Karolinska Institutet.


In 1953, Sven-Ivar Seldinger developed a technique for inserting catheters into the blood vessels via an Introducer. The method used in all hospitals throughout the world to insert catheters into the bloodstream via an Introducer.


Technology and innovation

Using this as inspiration, Staffan Holmin’s team developed the Extroducer, a novel device that uses the same Seldinger principal to exit blood vessels and reach the adjacent tissues. Large animal proof of principal studies at the Karolinska Institutet in tissues, such as heart, kidney, pancreas, and liver, have been performed.


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The Extroducer can be integrated with most off-the-shelf microcatheters and navigated into the microvasculature.