Regenerative Medicines

Our science

At SmartCella we specialize in SMART cell-based therapies. With our proprietary and highly efficient human pluripotent stem cell (hPSC) differentiation protocols, we are developing first-in-class allogeneic regenerative medicines with clinical indications including advanced heart failure and Parkinson’s disease.Leveraging our extensive expertise in hPSC differentiation, SmartCella has expanded our pipeline to include novel modified cell therapies to tackle an even broader range of disease indications through prolonged and sustained protein expression via our proprietary induced mesenchymal stem cell platform with targeted mRNA delivery.

Pipeline

SMART01

SMART02

SMART03

Cell Therapies

Our current allogeneic stem cell therapy platform is being developed by our ProCella business unit. The ProCella pipeline consists of stem/progenitor cells obtained from the differentiation of hPSCs as regenerative medicines to address conditions including heart failure and Parkinson’s disease.

Our lead program, SMART01, utilizes allogeneic cryopreserved Human Ventricular Progenitor cells (HVPs) derived from hPSCs to regenerate cardiac tissue in patients with advanced heart failure with reduced ejection fraction (HFrEF). SMART01 is entering a Phase 1/2a trial for advanced heart failure in the UK.

SMART02 consists of cryopreserved allogeneic human ventral midbrain progenitor dopamine producing cells (mDAs) derived from PSCs for the treatment of Parkinson’s disease (PD). Grafted cell preparations have shown exceptional therapeutic performance in preclinical transplantation studies in parkinsonian rat models, suggesting potential to become a best-in-class cell product. Professor Johan Ericson (Karolinska Institutet) and his team have developed a novel method to differentiate PSCs into mDA neurons progenitor cells with improved efficiency and yield in therapeutic mDA neurons after transplantation. We have built upon Ericson’s work to develop our SMART02 program.

Interested to learn more about our novel SMART cell-based therapies? Please reach out.

Modified Cell Therapies

Our cell-based mRNA delivery technology is being developed by our Solutions business unit. This platform leverages a first in class approach that combines the innovation of hPSC differentiated mesenchymal stem cells with an mRNA therapeutic cargo for prolonged protein expression to create a truly novel regenerative therapy.

We are currently developing SMART03, our proprietary induced mesenchymal stem cell (iMSC) delivery platform, which builds on the paracrine anti-inflammatory properties of mesenchymal stem cells, paired with the sustained expression of regenerative factors for cartilage regeneration in osteoarthritis.

See our novel delivery device designed for cell therapies and other drug modalities.

Interested in using the Extroducer for your next delivery?